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RALDON 600 mg/g

Water Soluble Powder


Composition: each kg contains

Colistin sulphate 600 g

Pharmacokinetic

1- Colistin sulfate is that administered orally  it almost isn’t absorbed in  the  gastrointestinal  tract,  so  it  having  a  selective  and  specific activity  in  the  intestinal lumen against enterobacteria.

2- Colistin sulfate are  relatively stable  at  a pH  of  2–6,  but  they  become  unstable  at pH more than 6.

3- Colistin sulfate approximately 60% is excreted as unchanged drug in the urine during the first 24 hr after  dosing.

4- Colistin sulfate was  of  moderate  to  low  acute  oral  toxicity  but  was  of  higher  acute  toxicity  when administered  parenterally.

Pharmacodynamic

1.Colistin is a is a polypeptide antibiotic of polymyxin group

2.Colistin has bactericidal activity

3.Colistin active mainly  against  Gram negative bacteria, Escherichia coli,  Salmonella  spp. 

4.Colistin acts against many of which are strongly pathogen that cause diarrhea in calves and digestive system disorders in fowl.

Colistin  Mode of action

Colistin binds to LPSs and phospholipids in the outer cell membrane of Gram-negative bacteria. It competitively displaces divalent cations (Ca2+ and Mg2+) from the phosphate groups of membrane lipids, which leads to disruption of the outer cell membrane, leakage of intracellular contents and bacterial death

Indication:

Used  metaphilaxis in case of infections caused by non-invasive E.coli sensitive to Colistin.

Colistin acts against many of which are strongly pathogen that cause diarrhea in calves and digestive system disorders in fowl.

Dosage and Administration:

Administered in drinking water or milk at the dosage of 9-10 mg/kg b.w./day (equivalent to 5-6 mg Colistin sulphate/kg b.w.), for 3-7 days.

Preventive: 0.25 – 0.5 gm / L drinking water/3-5 days

Treatment :0.5-1 gm / L drinking water/3-5 days

Large animals: 45-50 mg/kg b.w./day (equivalent to 5-6 mg

Colistin sulphate/kg b.w.), for 3-7 days.

Package:

3 kg bag

Withdrawal Time

  • calves: 7 days
  • broilers: 1 day
  • turkeys: 1 day
  • rabbits: 5 days
  • eggs: 0 days